Mission Boost Grants (MBG) are designed to support select current and past ACS grantees specifically for the translation of their research to human testing. Mission Boost Grants are opportunities for ACS grantees to seek additional, or boost," resources for innovative, high-risk/high-reward projects. MBGs offer two stages of funding: Stage I requires the investigator to develop outcome-specific, unequivocal milestones that reduce the risks of studying a new drug, device, or procedure in patients. The topic of study may be the same that was previously funded by the ACS grant, but it is not required to be. Stage I MBG studies can be preclinical or clinical in nature. Stage II allows investigators to receive support for an additional period for advancing the research to clinical testing in cancer patients. Stage II MBG studies must involve testing in humans. To be considered for an MBG, research projects must focus on studies in cancer patients, such as: Treatment - First Time in Humans (FTIH); clinical proof-of-concept (PoC); side effect reduction; Diagnostics/Prognostics/Medical Devices - Clinical validation in humans; and Prevention - Including initial incidence or recurrence in humans (biomarker based/biomarker testing) and the identification and testing of interventions. Applicants must be either current or former ACS grantees or fellows; have held their ACS grant or fellowship for a minimum of one year; and are currently independent, full-time faculty at a not-for-profit, US-based research institution that has facilities and support to enable preclinical and clinical studies. Applicants must submit a Research Plan and Rationale. The Rationale for Stage I and Stage II are different. Applicants must also provide a list of collaborators, co-investigators, and consultants, and then directly upload a letter from each individual collaborator or consultant. The letter should outline the role that person will play with enough detail for evaluation of the value of the individual's contribution. A Statement of Institutional Support from the applicant's Department Chair or equivalent is also required. The deadlines are April 1 and October 15. Please visit the award's website for more information and the complete application process.