The HD Human Biology Project supports research that advances our understanding of Huntington's Disease as it occurs in people, through the use of patient samples, clinical data, and collaborations with HD clinics. HDSA encourages researchers to collaborate with one of its Centers of Excellence, but applicants may work with any HD clinic or research site worldwide. Projects should prioritize the use of clinical samples or data from HD patients and aim to generate findings that inform therapeutic development or improve patient care. We encourage applications that translate findings from HD models to human samples; develop or validate clinically meaningful biomarkers; explore novel therapeutic targets in human biological contexts; use or establish collaborations with HD clinics or Centers of Excellence; and apply emerging technologies (e.g., single-cell sequencing, wearables) to HD patient data. Applications should demonstrate a clear path toward improving our biological understanding of HD in people and/or advancing therapies or care. Those who may apply are researchers from academic, clinical, nonprofit, and for-profit institutions worldwide; investigators from all disciplines, including but not limited to neuroscience, genetics, data science, rehabilitation, engineering, and psychology; and early-career investigators and HD newcomers are especially encouraged. Preference given to early-career postdoctoral and clinical investigators (PhD and/or MD). Projects must involve human samples or data. iPSC-based studies must be clearly linked to human clinical relevance. Applicants must have, or establish, a collaboration with an HD clinical site. Mentored applications must include a letter of support from the mentor, who must have a PhD and/or MD/DO degree and have a primary appointment at academic, public or private research institutions. Please visit the award's website for more information.