FRAXA Clinical Trial Grant applications may be submitted at any time, and the budget is flexible. These grants are strictly for clinical research with human subjects who have Fragile X. Flexible in amount, structure, and duration, but may be subject to some negotiation. Emphasis will be placed on clinical trials of potentially disease-modifying agents which have been previously validated in Fragile X animal models. Other types of clinical research will also be considered, such as biomarker studies in Fragile X patients, or trials of symptomatic therapies. No limit to structure of grant (can fund PI, postdoc, grad student, technician, supplies, etc.) or time-frame (though all grants over one year still need yearly renewal) No limit on amount, but please remember that applications are ranked based on relative value, so smaller requests have an advantage! Application note: A brief Letter of Intent to Michael Tranfaglia, MD is essential for all applications.